Thursday, 14 February 2013 20:19

Denosumab reduced wrist fracture in postmenopausal women with osteoporosis

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Upon further dissection of information from the FREEDOM trial, specialists affirmed that denosumab altogether upgraded sweep bone mineral thickness, mass and quality contrasted and placebo, plus altogether decreasing the danger for wrist crack.

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Specialist James A. Simon, MD, CCD, NCMP, FACOG, of George Washington University, and partners resolved the impacts of denosumab (Prolia, Xgeva; Amgen) on span cortical and trabecular skeletal substance thickness, mass, quality and wrist break frequency from the study in which postmenopausal ladies with osteoporosis (n=7,808) appropriated placebo or denosumab 60 mg each 6 months for 36 months.

James A. Simon

Consistent with scientists, denosumab fundamentally expanded areal BMD and volumetric BMD, bone mineral substance and polar minute of inactivity vs. placebo (all P<.05).

Information additionally demonstrate that wrist break frequency was 2.9% for placebo and 2.5% for denosumab with a RR decrease of 16% (P=.21) at 36 months. Besides, patients with a femoral neck T-score of –2.5 or easier had an expanded hazard for wrist break. The specialists composed that denosumab fundamentally diminished the rate of wrist break (2.4%) contrasted and placebo (4%), with a RR decrease of 40% and a total danger decrease of 1.6% (P=.03).

As per the specialists, the aforementioned discoveries affirm formerly reported enhancements to sweep BMD after denosumab help in postmenopausal ladies with osteoporosis.

Divulgence: Several specialists report money related ties with Abbott, Agile Therapeutics, Amgen, Ascend Therapeutics, Azur Pharma, Bayer, BioSante Pharmaceuticals, Boehringer Ingelheim, Depomed, Eli Lilly, Endoceutics, Fabre-Kramer Pharmaceuticals, KV Pharmaceutical, Laboratoire HRA Pharma, Meditrina Pharmaceuticals, Merck, Merrion Pharmaceuticals, NDA Partners, Novartis, Novo Nordisk, Novogyne Pharmaceuticals, Nycomed, Pfizer, Polpharma, Roche, Sanofi-Aventis, Servier, Shionogi, Slate Pharmaceutical, Sprout Pharmaceuticals, Teva, Trovis Pharmaceuticals, United Osteoporosis Centers, Warner Chilcott, Watson Pharmaceuticals and Zentiva.

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